Reactions of α-substituted glycine derivatives with stannanes

Abstract

α-Benzoyloxy- and α-methoxy-substituted glycine derivatives are more stable than the corresponding bromides, yet they undergo analogous reactions with stannanes. Their reactions with mixtures of hexabutylditin and dialkyl disulphides give α-alkylthio-substituted glycine derivatives, a procedure that is applicable to the synthesis of cross-linked amino acid derivatives. Show more