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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

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Date

2009

Authors

Randall, Katrina
Lambe, Teresa
Johnson, Andy L
Treanor, Bebhinn
Kucharska, Edyta
Domaschenz, Heather
Whittle, Belinda
Tze, Lina
Enders, Anselm
Crockford, Tanya

Journal Title

Journal ISSN

Volume Title

Publisher

Nature Publishing Group

Abstract

To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/33188

Collections

Open Access Research

Source

Nature Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/ni.1820

Restricted until

2037-12-31

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Description
01_Randall_Dock8_mutations_cripple_B_cell_2009.pdf (1.68 MB)

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