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Elevated Lymphocyte Expression of CLIP Is associated with Type 1 Diabetes and May Be a Useful Marker of Autoimmune Susceptability

Date

Authors

Silva, Diego

Socha, L

Correcha, Manuel

Petrovsky, Nikolai

Publisher

New York Academy of Sciences

Abstract

Type 1 diabetes (T1D) susceptibility in humans and in the non-obese diabetic mouse is linked to MHC class II molecules characterized by an amino acid substitution at position 57 of the beta-chain (nonAspB57). The mechanism whereby nonAspB57 MHC molecules

Keywords

Keywords: fluorescein isothiocyanate; major histocompatibility antigen class 2; protein CLIP; unclassified drug; amino acid substitution; antigen binding; antigen expression; antigen presentation; autoimmunity; clinical article; conference paper; controlled study; Antigen processing; Autoimmunity; CLIP; Type 1 diabetes

URI

http://hdl.handle.net/1885/82829

Collections

Open Access Research

Source

Annals of the New York Academy of Sciences

Type

Journal article

DOI

10.1196/annals.1337.009

Restricted until

2037-12-31

Downloads

File

Description

01_Silva_Elevated_Lymphocyte_Expression_2004.pdf (701.97 KB)