Stereocontrolled total synthesis of apicularen A and its Δ17,18 Z isomer

Nicolaou, K. C.; Kim, David W.; Baati, Rachid

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Stereocontrolled total synthesis of apicularen A and its Δ17,18 Z isomer

Date

2002-10-04

Authors

Nicolaou, K. C.

Kim, David W.

Baati, Rachid

Abstract

Mimicking nature's biosynthetic pathway to polyketides, a two-step procedure involving allylation followed by ozonolysis was applied five times in total for the construction of the carbon skeleton of apicularen A (1). Application of the developed synthetic technology also establishes an entry into designed apicularen analogues.