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Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain

Date

Authors

Blackburn, Anneke

McLary, S Christine

Naaem, Rizwan

Publisher

American Association for Cancer Research

Abstract

Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes and promoting tumor progression. BALB/c-Trp53 +/- mice are a model of Li-Fraumeni syndrome, exhibiting a high frequency of mammary tumors and other tumor

Keywords

Keywords: animal cell; animal experiment; animal model; animal tissue; article; breast carcinogenesis; breast tumor; chromosome 11; chromosome loss; comparative genomic hybridization; controlled study; disease predisposition; DNA repair; DNA strand breakage; famili

URI

http://hdl.handle.net/1885/17191

Collections

Open Access Research

Source

Cancer Research

Type

Journal article

DOI

10.1158/0008-5472.CAN-03-3435

Restricted until

2037-12-31

Downloads

File

Description

01_Blackburn_Loss_of_heterozygosity_occurs_2004.pdf (266.6 KB)