Efficient nickel/N-heterocyclic carbene catalyzed C-S cross-coupling

Guan, Pei; Cao, Changsheng; Liu, Yun; Li, Yunfei; He, Pan; Chen, Qian; Liu, Gang; Shi, Yanhui

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Efficient nickel/N-heterocyclic carbene catalyzed C-S cross-coupling

Date

2012-11-07

Authors

Abstract

The cross-coupling reaction of aryl halides with aliphatic and aromatic thiols catalyzed by readily available Ni(OAc) 2 with N-heterocyclic carbene (NHC) is reported. Ni(OAc) 2/NHC catalyst showed good activities toward various aryl halides in C-S coupling reaction, even with aryl chlorides. Reactions occurred in excellent yields, broad scope, and high tolerance of functional groups.