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Physico-chemical modelling of target depletion during hybridization on oligonulceotide microarrays

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Burden, Conrad
Binder, Hans

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Institute of Physics Publishing

Abstract

The effect of target molecule depletion from the supernatant solution is incorporated into a physico-chemical model of hybridization on oligonucleotide microarrays. Two possible regimes are identified: local depletion, in which depletion by a given probe

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Physical Biology

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Restricted until

2037-12-31