Glutathione transferase zeta: novel xenobiotic substrates and enzyme inactivation

Anders, Michael; Anderson, Wayne; Tzeng, Huey-Fen; Board, Philip

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Glutathione transferase zeta: novel xenobiotic substrates and enzyme inactivation

Date

2001

Authors

Anders, Michael

Anderson, Wayne

Tzeng, Huey-Fen

Board, Philip

Publisher

Elsevier

Abstract

Glutathione transferase zeta (GSTZ1-1) catalyzes the biotransformation of a range of α-haloalkanoates and the isomerization of maleylacetoacetate to furmarylacetoacetate. The elimination half-life of DCA is increased in human subjects or rats given singl

Keywords

Keywords: Dichloroacetate; Enzyme inactivation; Glutathione transferase zeta; Maleylacetoacetate isomerase

URI

http://hdl.handle.net/1885/89443

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Open Access Research

Source

Chemico-Biological Interactions

Type

Journal article

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Glutathione transferase zeta: novel xenobiotic substrates and enzyme inactivation

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