Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

Cui, Hao; Hung, Amos C; Freeman, Craig; Narkowicz, Christian; Jacobsen, Glenn A.; Small, David H

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Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

Date

2012

Authors

Cui, Hao

Hung, Amos C

Freeman, Craig

Narkowicz, Christian

Jacobsen, Glenn A.

Small, David H

Publisher

Blackwell Publishing Ltd

Abstract

Alzheimer's disease is associated with abnormal accumulation of Aβ, which is produced from the β-amyloid precursor protein (APP) by the β-site APP-cleaving enzyme (BACE1) and Î-secretase. Our previous studies showed that heparin can decrease APP proce

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http://hdl.handle.net/1885/67298

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Open Access Research

Source

Journal of Neurochemistry

Type

Journal article

DOI

10.1111/j.1471-4159.2012.07929.x

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2037-12-31

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Size and sulfation are critical for the effect of heparin on APP processing and Aβ production

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