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Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance

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Date

2008

Authors

Goldsworthy, Michelle
Hugill, Alison
Freeman, Helen
Horner, Emma
Shimomura, Kenju
Bogani, Debora
Pieles, Guido
Mijat, Vesna
Arkell, Ruth
Bhattacharya, Shoumo

Journal Title

Journal ISSN

Volume Title

Publisher

American Diabetes Association

Abstract

OBJECTIVES-To identify, map, clone, and functionally validate a novel mouse model for impaired glucose tolerance and insulin secretion. RESEARCH DESIGN AND METHODS-Haploinsufflciency of the insulin receptor and associated mild insulin resistance has been

Description

Keywords

Keywords: adenosine triphosphatase (potassium); ethylnitrosourea; insulin receptor; small interfering RNA; transcription factor Sox4; calcium; glucose; high mobility group protein; insulin; Sox4 protein, mouse; transactivator protein; animal cell; animal cell cultu

Citation

URI

http://hdl.handle.net/1885/59461

Collections

Open Access Research

Source

Diabetes

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.2337/db07-0337

Restricted until

2037-12-31

Downloads

File
Description
01_Goldsworthy_Role_of_the_Transcription_2008.pdf (1.04 MB)

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