Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

Rockett, K. A.; Awburn, M. M.; Cowden, W. B.; Clark, I. A.

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Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

Date

1991

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Abstract

We have investigated the in vitro susceptibility of the human malaria parasite Plasmodium falciparum to killing by nitric oxide and related molecules. A saturated solution of nitric oxide did not inhibit parasite growth, but two oxidation products of nitric oxide (nitrite and nitrate ions) were toxic to the parasite in millimolar concentrations. Nitrosothiol derivatives of cysteine and glutathione were found to be about a thousand times more active (50% growth inhibitory concentration, approximately 40 μM) than nitrite.

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https://dspace-test.anu.edu.au/handle/1885/733729694

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DevOps Pure Testing

Source

Infection and Immunity

Type

Comment/debate

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Killing of Plasmodium falciparum in vitro by nitric oxide derivatives

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