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The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-kB-Dependent c-myc Expression

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Date

2004

Authors

Grumont, Raelene
Lock, Peter
Shannon, M Frances
Moore, Anna
Gerondakis, Steve
Mollinari, Michael

Journal Title

Journal ISSN

Volume Title

Publisher

Cell Press

Abstract

Cell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-κB1 and c-Rel transcription factors. Here, we show that c-myc-dependent growth during T cell activation requires

Description

Keywords

Keywords: protein kinase C theta; transcription factor Rel; article; cell cycle G1 phase; cell size; gene expression; genetic transcription; nuclear import; oncogene c myc; priority journal; T lymphocyte; T lymphocyte activation; Animals; Cell Size; DNA-Binding Pro

Citation

URI

http://hdl.handle.net/1885/85970

Collections

Open Access Research

Source

Immunity

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.immuni.2004.06.004

Restricted until

2037-12-31

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Description
01_Grumont_The_Mitogen-Induced_Increase_2004.pdf (574.89 KB)

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