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Two siblings with lethal pneumococcal meningitis in a family with a mutation in Interleukin-1 receptor associated kinase 4

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Date

2004

Authors

Enders, Anselm
Pannicke, Ulrich
Berner, Reihnard
Henneke, Phillip
Radlinger, Klaus
Schwarz, Klaus
Ehl, Stephan

Journal Title

Journal ISSN

Volume Title

Publisher

Mosby Inc

Abstract

We describe two siblings with one confirmed and one inferred homozygous base pair deletion in the gene for interleukin-1-related kinase 4 (IRAK-4) who died of pneumococcal meningitis at 2 and 14 months, respectively. Interleukin-1-related kinase 4 deficiency is a potentially lethal immunodeficiency characterized by a poor inflammatory response to pyogenic infections.

Description

Keywords

Citation

URI

http://hdl.handle.net/1885/36665

Collections

Open Access Research

Source

Journal of Pediatrics

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.jpeds.2004.06.065

Restricted until

2037-12-31

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Description
01_Enders_Two_siblings_with_lethal_2004.pdf (85.97 KB)

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