Cross-conjugation in synthesis

Abstract

This chapter presents dendralene's diene-transmissive Diels-Alder (DTDA) chemistry with a focus toward those examples that best demonstrate the rapid generation of structural complexity. The chapter reviews an analysis of dendralenes, and then progress through the higher homologs. It reviews the application of dendralene DTDA chemistry in target-orientated synthesis. The majority of DTDA studies have been conducted on the simplest analogs, the dendralenes. The chapter classifies these reactions into examples that incorporate either an acyclic or cyclic dendralene. To date, the majority of studies have been conducted on 3-substituted systems as a consequence of their accessibility radialenes, and the control they offer over Diels-Alder (DA) site selectivity. The number of multicyclic frameworks that can be generated from acyclic dendralenes is greatly increased when intramolecular DA reactions. The chapter further explains the majority of reports involving DTDA sequences of these compounds are actually part of larger dendralene sequences. Show more