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Affinity-independent plasma cell differentiation in germinal centers

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Date

2024

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Abstract

The role of antibody affinity in plasma cell (PC) differentiation from germinal centers (GCs) remains contested. Parallel studies by Sprumont et al. and Sutton and Gao et al. show that PCs emerging from GCs produce antibodies with a diverse range of affinities and lack signatures of affinity-based selection. Therefore, commitment to the PC lineage is affinity independent.

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Citation

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https://dspace-test.anu.edu.au/handle/1885/733725706

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DevOps Pure Testing

Source

Trends in Immunology

Type

Short survey

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DOI

10.1016/j.it.2024.03.002

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